Spatio-temporal expression of Peroxisome Proliferator-Activated Receptor a During Human Prenatal Development

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33152398" target="_blank" >RIV/61989592:15110/15:33152398 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12326/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12326/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.12326" target="_blank" >10.1111/bcpt.12326</a>

Result language
angličtina
Original language name
Spatio-temporal expression of Peroxisome Proliferator-Activated Receptor a During Human Prenatal Development
Original language description
Peroxisome proliferator-activated receptor a (PPARa) is a ligand-dependent transcription factor which is activated by various endogenous as well as exogenous compounds. It is involved in the regulation of a variety of biological processes, such as nutrient metabolism, energy homoeostasis, immunological response and xenobiotic metabolism. Little is known about its expression during human prenatal development. We examined the spatio-temporal expression pattern of PPARa in human embryonic/foetal intestines, liver and kidney from the 5th to 20th week of prenatal life by indirect two-step immunohistochemistry. PPARa expression can already be detected in the early stages of prenatal development; as early as the 7th week of intrauterine development (IUD) in the intestines, 5th week of IUD in the liver and 6th week of IUD in the kidney. We found agedependent changes in the PPARa expression pattern in the intestines and kidney. These events occur approximately at the commencement of function of
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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