Soluble Epoxide Hydrolase as a Potential Key Factor for Human Prenatal Development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A73579961" target="_blank" >RIV/61989592:15110/16:73579961 - isvavai.cz</a>

Result on the web

<a href="https://www.karger.com/Article/FullText/444674" target="_blank" >https://www.karger.com/Article/FullText/444674</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000444674" target="_blank" >10.1159/000444674</a>

Result language

angličtina

Original language name

Soluble Epoxide Hydrolase as a Potential Key Factor for Human Prenatal Development

Original language description

Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids. Because of the role of EETs in processes potentially relevant to the development of organisms, EETs could be suggested as potential morphogens. Unfortunately, only little is known about sEH expression during human intrauterine development (IUD). We investigated the spatio-temporal expression pattern of sEH in human embryonic/foetal intestines, liver and kidney from the 6th to the 20th week of IUD by two-step immunohistochemistry. sEH was expressed during the whole tested period of prenatal development and its level of expression remained more or less the same during the estimated period of IUD. Distribution of CYP epoxygenases and sEH in the intestinal epithelium and the nephrogenic zone of the kidney suggests an influence of EETs on cell proliferation and differentiation and, consequently, on the development of intestines and kidney.Thus, alterations in the strict spatio-tempo-ral pattern of expression of CYP epoxygenases and/or sEH during human prenatal development by xenobiotics could have a harmful impact for developing organisms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells Tissues Organs

ISSN

1422-6405

e-ISSN

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Volume of the periodical

2016

Issue of the periodical within the volume

201

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

277-286

UT code for WoS article

000376570000004

EID of the result in the Scopus database

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