Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591231" target="_blank" >RIV/61989592:15110/18:73591231 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.taap.2018.06.025" target="_blank" >http://dx.doi.org/10.1016/j.taap.2018.06.025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.taap.2018.06.025" target="_blank" >10.1016/j.taap.2018.06.025</a>
Alternative languages
Result language
angličtina
Original language name
Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.
Original language description
CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). EETs are very biologically active molecules. They promote proliferation and inhibit apoptosis. Peroxisome proliferator-activated receptor α (PPARα) play role in regulation of CYP epoxygenases and sEH. PPARα is the ligand-dependent transcriptional factor which is activated by various compounds, including fibrates. The results demonstrate that the effect of fibrates on arachidonic acid-metabolizing enzymes expression is concentration-dependent. Although CYP2C8 expression is downregulated by the fibrates treatment, the results reveal that changes in CYP2J2 / sEH ratio are closely associated with cell proliferation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
TOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN
0041-008X
e-ISSN
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Volume of the periodical
2018
Issue of the periodical within the volume
září
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
156-163
UT code for WoS article
000442193300016
EID of the result in the Scopus database
2-s2.0-85049556840