Phase II Drug Metabolism

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33116400" target="_blank" >RIV/61989592:15110/12:33116400 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28110/12:43868798
Result on the web
<a href="http://dx.doi.org/10.5772/29996" target="_blank" >http://dx.doi.org/10.5772/29996</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/29996" target="_blank" >10.5772/29996</a>

Result language
angličtina
Original language name
Phase II Drug Metabolism
Original language description
All organisms are constantly and unavoidably exposed to xenobiotics including both man-made and natural chemicals such as drugs, plant alkaloids, microorganism toxins, pollutants, pesticides, and other industrial chemicals. Formally, biotransformation ofxenobiotics as well as endogenous compounds is subdivided into phase I and phase II reactions. This chapter focuses on phase II biotransformation reactions (also called 'conjugation reactions') which generally serve as a detoxifying step in metabolism of drugs and other xenobiotics as well as endogenous substrates. On the other hand, these conjugations also play an essential role in the toxicity of many chemicals due to the metabolic formation of toxic metabolites such as reactive electrophiles. Gene polymorphism of biotransformation enzymes may often play a role in various pathophysiological processes. Conjugation reactions usually involve metabolite activation by a high-energy intermediate and have been classified into two general ty
Czech name
—
Czech description
—

Project
<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)