Regulation of Phase II Biotransformation Enzymes by Steroid Hormones
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33117040" target="_blank" >RIV/61989592:15310/11:33117040 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Regulation of Phase II Biotransformation Enzymes by Steroid Hormones
Original language description
Phase II biotransformation enzymes conjugate xenobiotics using small, organic donor molecules, such as glutathione, UDPglucuronic acid, S-adenosyl-L-methionine, acetyl coenzyme A and amino acids (primarily glycine). These reactions generally resulted indetoxification by the loss of pharmacological activity and by quickening the elimination of xenobiotics from the body, however bioactivation is also known to be occured. Historically, it was placed more emphasis on research of phase I than of phase II enzymes. Nevertheless, it is well known that conjugation enzymes play an important role in drug and toxicant disposition since they can dramatically alter pharmacokinetics and therefore therapeutic efficacy and toxicity of drugs. In this context surprisingly, the exact regulation mechanism of phase II conjugation enzymes expression is not fully understood. However, available experimental data suggest that several transcriptional factors are involved in this process. In the current review,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Drug Metabolism
ISSN
1389-2002
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
2
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
20
Pages from-to
104-123
UT code for WoS article
000289085500004
EID of the result in the Scopus database
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