Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138480" target="_blank" >RIV/61989592:15110/12:33138480 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.leukres.2011.12.014" target="_blank" >http://dx.doi.org/10.1016/j.leukres.2011.12.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.leukres.2011.12.014" target="_blank" >10.1016/j.leukres.2011.12.014</a>

Result language

angličtina

Original language name

Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)

Original language description

In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new "acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)" was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia Research

ISSN

0145-2126

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

"e-68"-"e-70"

UT code for WoS article

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EID of the result in the Scopus database

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