Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138723" target="_blank" >RIV/61989592:15110/12:33138723 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1471-2172-13-25" target="_blank" >http://dx.doi.org/10.1186/1471-2172-13-25</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2172-13-25" target="_blank" >10.1186/1471-2172-13-25</a>

Result language

angličtina

Original language name

Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection

Original language description

BACKGROUND: Prosthetic joint infection (PJI) is an important failure mechanism of total joint arthroplasty (TJA). Here we examine whether the particular genetic variants can lead to increased susceptibility to PJI development. RESULTS: We conducted a genetic-association study to determine whether PJI could be associated with functional cytokine gene polymorphisms (CGP) influencing on innate immunity response. A case-control design was utilized and previously published criteria for PJI were included to distinguish between cases and control subjects with/without TJA. Six single nucleotide polymorphisms (SNPs) located in the genes for interleukin-1beta (SNP: IL1B-511, +3962), tumour necrosis factor alpha (TNF-308, -238) and interleukin-6 (IL6-174, nt565)were genotyped in 303 Caucasian (Czech) patients with TJA (89 with PJI / 214 without PJI), and 168 unrelated healthy Czech individuals without TJA. The results showed that carriers of the less common IL1B511*T allele were overrepresented

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/NS10260" target="_blank" >NS10260: Individual susceptibility to periprosthetic joint infection: a role of variants in genes coding for innate immunity receptors and for chemotactic / proinflammatory cytokines</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Immunology

ISSN

1471-2172

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1-8

UT code for WoS article

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EID of the result in the Scopus database

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