Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33143925" target="_blank" >RIV/61989592:15110/13:33143925 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/13:#0000517

Result on the web

<a href="http://dx.doi.org/10.1007/s00011-013-0601-8" target="_blank" >http://dx.doi.org/10.1007/s00011-013-0601-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00011-013-0601-8" target="_blank" >10.1007/s00011-013-0601-8</a>

Result language

angličtina

Original language name

Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection

Original language description

OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 andTLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphismsof the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by "TaqMan" assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/hea

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inflammation Research

ISSN

1023-3830

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

483-487

UT code for WoS article

000317647400005

EID of the result in the Scopus database

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