Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138726" target="_blank" >RIV/61989592:15110/12:33138726 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2012.023" target="_blank" >http://dx.doi.org/10.5507/bp.2012.023</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2012.023" target="_blank" >10.5507/bp.2012.023</a>

Result language
angličtina
Original language name
Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population
Original language description
Background and aims. Prosthetic Joint Infection (PJI) is a serious complication of Total Joint Arthroplasty (TJA). The Th-17 immune response characterised by IL (interleukin)-17A, IL-17F, IL-23, chemotactic cytokines and their receptors, plays a prominent role in the immune response to invading bacteria. In addition, high expression of IL-17A has been reported in PJI. The aim of this study was to investigate whether genetic variation in the key molecules of the Th-17 immune response can affect the riskfor PJI. Methods: Altogether ten Single Nucleotide Polymorphisms (SNPs) of IL17A (rs2275913), IL17F (rs763780), IL4 (rs2243250), IL12A (rs583911), IL12B (rs3212227 and (rs17860508), IL23R (rs7517847), CXCL1 (rs4074), CXCL5 (rs425535) and CXCR2 (rs2230054) genes were genotyped by PCR with sequence specific primers (SSP) in 98 patients with PJI and two kontrol groups 1) an aseptic TJA control (253 patients with TJA that did not develop PJI at least 6 yrs. after the surgery) and 2) a popula
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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