BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140001" target="_blank" >RIV/61989592:15110/12:33140001 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0022510X12002195?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022510X12002195?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2012.05.008" target="_blank" >10.1016/j.jns.2012.05.008</a>
Alternative languages
Result language
angličtina
Original language name
BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke
Original language description
Investigations were performed to localize and analyze the botulinum toxin (BoNT-A) related changes of cerebral cortex activation in chronic stroke patients suffering from severe hand paralysis with arm spasticity. Effects on task- related cerebral activation were evaluated by functional magnetic resonance imaging (fMRI). Methods: 14 patients (5 males, 9 females,mean age 55.3 years) suffering from upper limb post-stroke spasticity were investigated. The change of armspasticitywas assessed by using the modified Ashworth scale (MAS). FMRI sessionswere performed before (W0), four weeks (W4) and 11 weeks (W11) after BoNT-A application. Patients were scannedwhile performing imaginarymovementwith the impaired hand. Group fMRI analysis included patient age as a covariate. Results: BoNT-A treatmentwas effective in alleviation of armspasticity. Mean MASwas at Week 0: 2.5 (SD 0.53), at Week 4: 1.45 (SD 0.38), at Week 11: 2.32 (SD 0.44). Task-related fMRI prior to the treatment showed extensive activation of bilateral frontoparietal sensorimotor cortical areas, anterior cingulate gyrus, pallidum, thalamus and cerebellum. Effective BoNT-A treatment (W4) resulted in partial reduction of active network volume inmost of the observed areas, whereas BoNT-free data (W11) revealed further volume reduction in the sensorimotor network. On direct comparison, significant activation decreases associated with BoNT-A treatment were located in areas outside the classical sensorimotor system, namely, ipsilesional lateral occipital cortex, supramarginal gyrus and precuneus cortex. On comparison of W4 and W11, no activation increases were found, instead, activation further decreased in ipsilesional insular cortex, contralesional superior frontal gyrus and bilateral frontal pole.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NS9920" target="_blank" >NS9920: Changes of motor and premotor cortex organization and activation following botulinum toxin injection in ischemic stroke patients suffering from spasticity: an fMRI study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the Neurological Sciences
ISSN
0022-510X
e-ISSN
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Volume of the periodical
319
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
89-95
UT code for WoS article
000306246900018
EID of the result in the Scopus database
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