BoNT-A related changes of cortical activity in patients suffering from severe hand

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F12%3A33140001" target="_blank" >RIV/61989592:15120/12:33140001 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jns.2012.05.008" target="_blank" >http://dx.doi.org/10.1016/j.jns.2012.05.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2012.05.008" target="_blank" >10.1016/j.jns.2012.05.008</a>

Result language

angličtina

Original language name

BoNT-A related changes of cortical activity in patients suffering from severe hand

Original language description

Investigations were performed to localize and analyze the botulinum toxin (BoNT-A) related changes of cerebral cortex activation in chronic stroke patients suffering from severe hand paralysis with arm spasticity. Effects on task- related cerebral activation were evaluated by functional magnetic resonance imaging (fMRI). Methods: 14 patients (5 males, 9 females,mean age 55.3 years) suffering from upper limb post-stroke spasticity were investigated. The change of armspasticitywas assessed by using the modified Ashworth scale (MAS). FMRI sessionswere performed before (W0), four weeks (W4) and 11 weeks (W11) after BoNT-A application. Patients were scannedwhile performing imaginarymovementwith the impaired hand. Group fMRI analysis included patient age asa covariate. Results: BoNT-A treatmentwas effective in alleviation of armspasticity. Mean MASwas at Week 0: 2.5 (SD 0.53), at Week 4: 1.45 (SD 0.38), at Week 11: 2.32 (SD 0.44). Task-related fMRI prior to the treatment showed extensive ac

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NS9920" target="_blank" >NS9920: Changes of motor and premotor cortex organization and activation following botulinum toxin injection in ischemic stroke patients suffering from spasticity: an fMRI study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

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Volume of the periodical

319

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

89-95

UT code for WoS article

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EID of the result in the Scopus database

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