High serum carbohydrate antigen-125 (CA-125) level predicts poor outcome in patients with follicular lymphoma independently of the FLIPI score

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140217" target="_blank" >RIV/61989592:15110/12:33140217 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12185-012-1102-1" target="_blank" >http://dx.doi.org/10.1007/s12185-012-1102-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12185-012-1102-1" target="_blank" >10.1007/s12185-012-1102-1</a>

Result language

angličtina

Original language name

High serum carbohydrate antigen-125 (CA-125) level predicts poor outcome in patients with follicular lymphoma independently of the FLIPI score

Original language description

Carbohydrate antigen-125 (CA-125) was established as a prognostic marker in cancer, especially in ovarian carcinoma. Many recent studies have also reported on the prognostic significance of CA-125 in patients with different types of lymphoma, but only afew studies have been carried out in patients treated with rituximab or high-dose therapy. The prognostic impact of CA-125 on a large cohort of patients with follicular lymphoma (FL) has not been studied. This study analyzed the prognostic significance of CA-125 levels in 116 prospectively enrolled patients with previously untreated FL. It showed that the CA-125 level at the time of treatment initiation correlates with the clinical stage, number of involved nodal areas, bulky disease, hemoglobin level,beta-2 microglobulin level, and lactate dehydrogenase level. Patients with CA-125 }35 U/mL had significantly shorter progression-free (p { 0.001) and overall (p = 0.025) survival rates. Cox regression analysis identified high CA-125 level

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Hematology

ISSN

0925-5710

e-ISSN

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Volume of the periodical

96

Issue of the periodical within the volume

1

Country of publishing house

JP - JAPAN

Number of pages

7

Pages from-to

58-64

UT code for WoS article

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EID of the result in the Scopus database

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