Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140827" target="_blank" >RIV/61989592:15110/12:33140827 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/12:00387884
Result on the web
<a href="http://dx.doi.org/10.4161/cc.19978" target="_blank" >http://dx.doi.org/10.4161/cc.19978</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/cc.19978" target="_blank" >10.4161/cc.19978</a>
Alternative languages
Result language
angličtina
Original language name
Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage
Original language description
The cellular DNA damage response (DDR) machinery that maintains genomic integrity and prevents severe pathologies, including cancer, is orchestrated by signaling through protein modifications. Protein ubiquitylation regulates repair of DNA double-strandbreaks (DSBs), toxic lesions caused by various metabolic as well as environmental insults such as ionizing radiation (IR). Whereas several components of the DSB-evoked ubiquitylation cascade have been identified, including RNF168 and BRCA1 ubiquitin ligases, whose genetic defects predispose to a syndrome mimicking ataxiatelangiectasia and cancer, respectively, the identity of the apical E1 enzyme involved in DDR has not been established. Here, we identify ubiquitin-activating enzyme UBA1 as the E1 enzyme required for responses to IR and replication stress in human cells. We show that siRNA-mediated knockdown of UBA1, but not of another UBA family member UBA6, impaired formation of both ubiquitin conjugates at the sites of DNA damage and
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CELL CYCLE
ISSN
1538-4101
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1573-1582
UT code for WoS article
000303162100019
EID of the result in the Scopus database
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