Methylation of AR locus does not always reflect X chromosome inactivation state
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33141042" target="_blank" >RIV/61989592:15110/12:33141042 - isvavai.cz</a>
Result on the web
<a href="http://bloodjournal.hematologylibrary.org/content/119/13/e100.full.pdf+html" target="_blank" >http://bloodjournal.hematologylibrary.org/content/119/13/e100.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2011-11-390351" target="_blank" >10.1182/blood-2011-11-390351</a>
Alternative languages
Result language
angličtina
Original language name
Methylation of AR locus does not always reflect X chromosome inactivation state
Original language description
Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpGsites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular bas
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood
ISSN
0006-4971
e-ISSN
—
Volume of the periodical
119
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"e100"-"e109"
UT code for WoS article
000302141200001
EID of the result in the Scopus database
—