NQO1 expression correlates inversely with NF kappa B activation in human breast cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33141807" target="_blank" >RIV/61989592:15110/12:33141807 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10549-011-1629-5" target="_blank" >http://dx.doi.org/10.1007/s10549-011-1629-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10549-011-1629-5" target="_blank" >10.1007/s10549-011-1629-5</a>
Alternative languages
Result language
angličtina
Original language name
NQO1 expression correlates inversely with NF kappa B activation in human breast cancer
Original language description
NQO1 participates in cellular defense against oxidative stress and regulates apoptosis via p53- and NF kappa B-mediated pathways. We have previously found that homozygous missense variant NQO1*2 (rs1800566) predicts poor survival among breast cancer patients, particularly after anthracycline-based adjuvant chemotherapy. Here, we investigated NQO1 and NF kappa B protein expression and global gene expression profiles in breast tumors with correlation to tumor characteristics and survival after adjuvant chemotherapy. We used immunohistochemical analysis of tissue microarrays to study NQO1 and NF kappa B expression in two series of tumors: 1000 breast tumors unselected for treatment and 113 from a clinical trial comparing chemotherapy regimens after anthracycline treatment in advanced breast cancer. We used gene expression arrays to define genes co-expressed with NQO1 and NF kappa B. NQO1 and nuclear NF kappa B were expressed in 83% and 11% of breast tumors, and correlated inversely (P = 0
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BREAST CANCER RESEARCH AND TREATMENT
ISSN
0167-6806
e-ISSN
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Volume of the periodical
132
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
955-968
UT code for WoS article
000303379800019
EID of the result in the Scopus database
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