NF-kappa B/p65 expression before and after treatment in rectal cancer patients undergoing neoadjuvant (chemo)radiotherapy and surgery: prognostic marker for disease progression and survival

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000142" target="_blank" >RIV/00064173:_____/16:N0000142 - isvavai.cz</a>

Alternative codes found

RIV/00064211:_____/16:N0000028 RIV/00064190:_____/16:N0000295 RIV/00216208:11110/16:10324394 RIV/00216208:11120/16:43911769

Result on the web

<a href="http://dx.doi.org/10.4149/317_151013N525" target="_blank" >http://dx.doi.org/10.4149/317_151013N525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/317_151013N525" target="_blank" >10.4149/317_151013N525</a>

Result language

angličtina

Original language name

NF-kappa B/p65 expression before and after treatment in rectal cancer patients undergoing neoadjuvant (chemo)radiotherapy and surgery: prognostic marker for disease progression and survival

Original language description

Nuclear factor-kappaB (NF-kappa B), especially p65 subunit, has been associated with origin and progression of cancer as well as with the resistance to radiotherapy and chemotherapy in experimental models. The aim of the present study was to determine expression of NF-kappa B/p65 in tumor specimens before and after treatment of rectal cancer patients and to evaluate possible relationship between expression of NF-kappa B/p65 before and after (chemo)radiotherapy, other tumor characteristics and the clinical outcome. Furthermore, NF-kappa B/p65 was studied in relationship to pathologic response to preoperative (chemo)radiotherapy. Fifty patients with rectal cancer undergoing neoadjuvant (chemo)radiotherapy and surgery were included in the study. Pre-treatment rectal cancer specimens were obtained from diagnostic colonoscopy. Post-treatment rectal cancer specimens were obtained from surgically removed part of the rectum with the tumor. NF-kappa B/p65 expression was determined by immunohistochemistry and analysis was performed both in biopsies and in post-treatment tumor samples. Cytoplasmic positivity in tumor cells and nuclear positivity in lymphocytes were detected. High NF-kappa B/p65 positivity in pre-treatment tumor samples was significantly associated with shortened overall survival (OS). Disease-free survival (DFS) tends to be shortened as well. In post-treatment tumor samples, high NF-kappa B/p65 positivity was neither associated with shortened OS nor with shortened DFS. In post-treatment samples residual tumor cells deeply infiltrating the wall of the rectum with high NF-kappa B/p65 expression were found.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/NR8053" target="_blank" >NR8053: Nuclear Factor-kappaB and radiotherapy in colorectal cancer</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

63

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

462-470

UT code for WoS article

000377058000017

EID of the result in the Scopus database

2-s2.0-84969716686