Dissociated invasively growing cancer cells with NF-kappaB/p65 positivity after radiotherapy: a new marker for worse clinical outcome in rectal cancer? Preliminary data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00001292" target="_blank" >RIV/00216208:11120/08:00001292 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/08:00001067

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dissociated invasively growing cancer cells with NF-kappaB/p65 positivity after radiotherapy: a new marker for worse clinical outcome in rectal cancer? Preliminary data

Original language description

Objectives: Nuclear factor-kappaB (NF-kappaB), especially p65 subunit, seems to be associated with origin and progression of cancer. The aim of the study was to determine expression of NF-kappaB/p65 in rectal cancer patients before and after radiotherapyas well as to assess the relationship between NF-kappaB/p65 expression, other tumor characteristics, and disease progression. Further aim was to evaluate whether expression of NF-kappaB/p65 in tumor tissue may serve as a predictive marker of patient outcome. Patients and methods Twenty-five patients with rectal cancer undergoing pre-operative radiotherapy were included in the study. Unirradiated rectal cancer specimens were obtained from diagnostic colonoscopy. Irradiated rectal cancer specimens were obtained from surgically removed part of the rectum with the tumor. NF-kappaB/p65 expression was determined by immunohistochemistry. Results Cytoplasmic positivity in cancer cells and nuclear positivity in lymphocytes were detected. In pos

Czech name

Disociované, invazivně rostoucí, NF-kappaB/p65 pozitivní nádorové buňky po radioterapii: nový marker horší prognózy rektálních karcinomů? Předběžná data

Czech description

Nukleární faktor -kappaB (NF-kappaB), zvláště jeho podjednotka p65byly studovány imunohistologicky ve tkáni 25 rektálních karcinomů, stejně tak jako v endoskopicky získaných vzorcích těchto nádorů, které byly odebrány před nasazením radioterapie. V reziduích části nádorů po ozáření byla zastižena cytoplazmatická pozitivita NF-kappaB/p65, tyto nádory vykazovaly klinicky horší celkové přežití a období bez onemocnění, což může být v budoucnosti použito k posouzení prognózy těchto nádorů

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

<a href="/en/project/NR8053" target="_blank" >NR8053: Nuclear Factor-kappaB and radiotherapy in colorectal cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical & Experimental Metastasis

ISSN

0262-0898

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

25

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

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UT code for WoS article

000256253200020

EID of the result in the Scopus database

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