The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33142327" target="_blank" >RIV/61989592:15110/12:33142327 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ki.2012.192" target="_blank" >http://dx.doi.org/10.1038/ki.2012.192</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ki.2012.192" target="_blank" >10.1038/ki.2012.192</a>
Alternative languages
Result language
angličtina
Original language name
The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy
Original language description
ERK activation was not associated with elevated galactose-deficient IgA1 or IgG specific for galactose-deficient IgA1 in the serum. In human mesangial cells in vitro, ERK activation through mesangial IgA1 receptor (CD71) controlled pro-inflammatory cytokine secretion and was induced by large-molecular-mass IgA1-containing circulating immune complexes purified from patient sera. ERK activation alters mesangial cell-podocyte crosstalk, leading to renal dysfunction in IgAN. Assessment of MAPK/ERK activation in diagnostic renal biopsies may predict the therapeutic efficacy of renin-angiotensin system blockers in IgAN.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Kidney International
ISSN
0085-2538
e-ISSN
—
Volume of the periodical
82
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
1284-1296
UT code for WoS article
000311892600008
EID of the result in the Scopus database
—