Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10224921" target="_blank" >RIV/61989592:15110/11:10224921 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System
Original language description
IgA nephropathy (IgAN), the most common glomerulonephritis, is characterized by mesangial IgA1-containing immunodeposits, proliferation of mesangial cells, and matrix expansion. Clinical onset is frequently heralded by synpharyngitic hematuria, macroscopic hematuria during an upper-respiratory tract infection. Clinical and laboratory data support a postulated extrarenal origin of the glomerular IgA1, likely derived from circulating immune complexes containing polymeric IgA1, deficient in galactose in the hinge-region O-glycans, bound by antiglycan antibodies. This aberrant IgA1 is produced by IgA1-secreting cells with abnormal activities of specific glycosyltransferases.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
EC - Immunology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Advances in Oto-Rhino-Laryngology
ISBN
978-3-8055-9722-7
ISSN
0065-3071
e-ISSN
—
Number of pages
4
Pages from-to
60-63
Publisher name
S. Karger AG
Place of publication
Basel
Event location
Asahikawa, Japan
Event date
Jul 7, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—