Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00558000" target="_blank" >RIV/61388971:_____/22:00558000 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/22:E0109630 RIV/00098892:_____/22:10157156 RIV/61989592:15110/22:73614602 RIV/00064203:_____/22:10438377 RIV/00216208:11130/22:10438377
Result on the web
<a href="https://jasn.asnjournals.org/content/33/5/908" target="_blank" >https://jasn.asnjournals.org/content/33/5/908</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1681/ASN.2021081086" target="_blank" >10.1681/ASN.2021081086</a>
Alternative languages
Result language
angličtina
Original language name
Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors
Original language description
Significance StatementIgA nephropathy (IgAN) is associated with mesangial deposition of aberrantly glycosylated IgA1 containing ? light chains and the association of upper respiratory or digestive tract infection with macroscopic hematuria. We found that peripheral blood Gd-IgA1(+) cells from IgAN patients express predominantly ? light chains and CCR9 and CCR10, compared with healthy controls. Furthermore, Gd-IgA1(+) cell populations in peripheral blood are enriched with plasmablasts/plasma cells. Therefore, IgAN is associated with an increased number of migratory Gd-IgA1-?(+) cells predestined for homing to upper respiratory and digestive tract mucosal tissues, where their final maturation and Gd-IgA1-? secretion may be stimulated during upper respiratory or digestive tract infections.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the American Society of Nephrology
ISSN
1046-6673
e-ISSN
1533-3450
Volume of the periodical
33
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
908-917
UT code for WoS article
000782054300001
EID of the result in the Scopus database
2-s2.0-85129780670