IL-6 and its role in IgA nephropathy development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00558971" target="_blank" >RIV/86652036:_____/22:00558971 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/22:73614603
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1359610122000235?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359610122000235?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cytogfr.2022.04.001" target="_blank" >10.1016/j.cytogfr.2022.04.001</a>
Alternative languages
Result language
angličtina
Original language name
IL-6 and its role in IgA nephropathy development
Original language description
IL-6 is considered one of the well characterized cytokines exhibiting homeostatic, pro-and anti-inflammatory activities, depending on the receptor variant and the induced intracellular cis-or trans-signaling responses. IL 6-activated pathways are involved in the regulation of cell proliferation, survival, differentiation, and cell metabolism changes.Deviations in IL-6 levels or abnormal response to IL-6 signaling are associated with several autoimmune diseases including IgA nephropathy (IgAN), one of most frequent primary glomerulonephritis worldwide. IgAN is associated with increased plasma concentration of IL-6 and increased plasma concentration of aberrantly galactosylated IgA1 immunoglobulin (Gd-IgA1). Gd-IgA1 is specifically recognized by autoantibodies, leading to the formation of circulating immune complexes (CIC) with nephritogenic potential, since CIC deposited in the glomerular mesangium induce mesangial cells proliferation and glomerular injury. Infection of the upper respiratory or digestive tract enhances IL-6 production and in IgAN patients is often followed by the macroscopic hematuria.This review recapitulates general aspects of IL-6 signaling and summarizes experimental evidences about IL-6 involvement in the etiopathogenesis of IgA nephropathy through the production of Gd-IgA1 and regulation of mesangial cell proliferation.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF16_025%2F0007397" target="_blank" >EF16_025/0007397: Recombinant Biotechnology and Immunotherapy Centre</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cytokine & Growth Factor Reviews
ISSN
1359-6101
e-ISSN
1879-0305
Volume of the periodical
66
Issue of the periodical within the volume
AUG 2022
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
1-14
UT code for WoS article
000819259100001
EID of the result in the Scopus database
2-s2.0-85129566894