Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146094" target="_blank" >RIV/61989592:15110/13:33146094 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s13105-012-0222-7" target="_blank" >http://dx.doi.org/10.1007/s13105-012-0222-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13105-012-0222-7" target="_blank" >10.1007/s13105-012-0222-7</a>
Alternative languages
Result language
angličtina
Original language name
Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations
Original language description
The question whether A3 adenosine receptor (A3AR) agonists, N6-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N6-(3-iodobenzyl)-adenosine-5?-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations withor without the involvement of A3AR has been a controversial issue for a long time. The initial findings suggesting that A3AR plays a crucial role in the induction of cell death upon treatment with micromolar concentrations of IB-MECA or Cl-IB-MECA were revised, however, the direct and unequivocal evidence is still missing. Therefore, the sensitivity of CHO cells transfected with human recombinant A3AR (A3-CHO) and their counter partner wild type CHO cells, which do not express any of adenosine receptors, to micromolar concentrations of IB-MECA and Cl-IB-MECA was studied. We observed that IB-MECA and Cl-IB-MECA exhibited a strong inhibitory effect on cell proliferation due to the blockage of cell cycle progression at G1/S and G2/M transi
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physiology and Biochemistry
ISSN
1138-7548
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
3
Country of publishing house
ES - SPAIN
Number of pages
13
Pages from-to
405-417
UT code for WoS article
000322730300006
EID of the result in the Scopus database
—