Expression of multidrug resistance protein 1and multidrug resistance-associated protein 1in peripheral blood lymphocytes amongst children and young adults

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146476" target="_blank" >RIV/61989592:15110/13:33146476 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/13:#0000453
Result on the web
<a href="http://dx.doi.org/10.5114/ceji.2013.39770" target="_blank" >http://dx.doi.org/10.5114/ceji.2013.39770</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5114/ceji.2013.39770" target="_blank" >10.5114/ceji.2013.39770</a>

Result language
angličtina
Original language name
Expression of multidrug resistance protein 1and multidrug resistance-associated protein 1in peripheral blood lymphocytes amongst children and young adults
Original language description
Multidrug resistance protein 1 (MDR1, ABCB1 or P-glycoprotein) and multidrug resistance-associated protein 1 (MRP1, ABCC1 or LT C4 transporter) are active membrane-associated efflux transporters with broad substrate specificity. The aim of this study wasto assess the physiological expression of these proteins in the peripheral blood lymphocytes (PBLs) and selected polymorphisms in genes for these proteins in healthy children and young adults. The PBLs MDR1 expression in 41 subjects (aged from 2 monthsto 22.5 years of age) and PBLs MRP1 in 40 subjects (aged from 2 months to 22 years of age) were determined by using a flow cytometry analysis with the indirect immunofluorescence staining technique. Genotyping of rs1045642 (C3435T) and rs3213619 (T-129C)single nucleotide polymorphisms (SNPs) in ABCB1 gene and rs45511401 (G671V) SNP in ABCC1 gene was performed with TaqMan probes and by direct sequencing. We found a statistically significant dependence of PBLs MDR1 (but not PBLs MRP1) exp
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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