Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33144966" target="_blank" >RIV/61989592:15110/13:33144966 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children

Original language description

It is influenced by the activity of the immune system and transports certain immunomodulatory drugs (e.g. glucocorticoids) from the intracellular to the extracellular space. Increased expression of the MDR1 protein in lymphocytes may therefore lead to undesirable reduction of lymphocytic concentration of these drugs. The aim of the study was to assess the systemic effect of asthma on the expression of the MDR1 protein in lymphocytes. The expression of MDR1 in peripheral blood lymphocytes (PBLs) was determined by a flow cytometry analysis with indirect immunofluorescence staining technique amongst 20 children (aged from 1.85 to 16.38 years) with newly diagnosed, mild persistent asthma (prior therapy) and amongst 30 healthy children (aged from 0.15 to 17.08 years). There was a significantly lower PBLs MDR1 expression (median MDR1 expression, p { 0.02) and a significantly lower proportion of the population of MDR1-positive PBLs as well (percentage of MDR1-postitive PBLs, p { 5.39.10-3)

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Alergie

ISSN

1212-3536

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

171-174

UT code for WoS article

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EID of the result in the Scopus database

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