Pathogenetic role of ETV6 fusion gene in leukemic transformation of myelodysplastic syndrome refractory anemia with excess blasts-1 with a new, rare translocation t(11;19)(q24.3;q13.12) and insertion ins(6;12)(p22.3p13)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33145790" target="_blank" >RIV/61989592:15110/14:33145790 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/14:#0000661

Result on the web

<a href="http://dx.doi.org/10.3109/10428194.2013.814127" target="_blank" >http://dx.doi.org/10.3109/10428194.2013.814127</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/10428194.2013.814127" target="_blank" >10.3109/10428194.2013.814127</a>

Result language

angličtina

Original language name

Pathogenetic role of ETV6 fusion gene in leukemic transformation of myelodysplastic syndrome refractory anemia with excess blasts-1 with a new, rare translocation t(11;19)(q24.3;q13.12) and insertion ins(6;12)(p22.3p13)

Original language description

Myelodysplastic syndrome (MDS) refers to a group of clonal disorders originating from hematopoietic stem cells, and is characterized by ineff ective diff erentiation of hematopoietic progenitors, bone marrow dysplasia, genetic instability and, often, a propensity to develop acute myeloid leukemia (AML). Th e molecular pathogenesis of MDS and the main cause for its progression to AML remain largely undefi ned. Early mutations in stem cells may cause diff erentiation arrest, leading to dysplasia, whereassubsequent defects aff ecting myeloid cell proliferation may cause the clonal expansion of aberrant cells and frank AML [1]. Although many chromosomal abnormalities have been detected in MDS, the genes involved in the pathogenesis have yet to be identified. According to a recently published new scoring system proposal, a total of fi ve prognostic subgroups were confi rmed, with 19 cytogenetic categories being defi ned [2]. With the exception of a complex karyotype, all detected chromoso

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia & Lymphoma

ISSN

1042-8194

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

950-953

UT code for WoS article

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EID of the result in the Scopus database

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