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68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33147593" target="_blank" >RIV/61989592:15110/14:33147593 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s11307-013-0654-7" target="_blank" >http://dx.doi.org/10.1007/s11307-013-0654-7</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11307-013-0654-7" target="_blank" >10.1007/s11307-013-0654-7</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms

  • Original language description

    Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and humanlung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MOLECULAR IMAGING AND BIOLOGY

  • ISSN

    1536-1632

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    102-108

  • UT code for WoS article

    000329793200013

  • EID of the result in the Scopus database