HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33149999" target="_blank" >RIV/61989592:15110/14:33149999 - isvavai.cz</a>
Result on the web
<a href="http://jvi.asm.org/content/88/24/14258.long" target="_blank" >http://jvi.asm.org/content/88/24/14258.long</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/JVI.02164-14" target="_blank" >10.1128/JVI.02164-14</a>

Result language
angličtina
Original language name
HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission
Original language description
The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure,surface exposure, and, consequently, antigenicity, infectivity, antibody neutralization, and carbohydrate and receptor binding. Studies of HIV-1 glycosylation have focused mainly on the position of glycosylation, rather than the types of glycans. Also,the role of Env glycan moieties on HIV-1 transmission has not been systematically defined. Using viruses with modified Env glycan content and heterogeneity, we examined the effects of Env glycan moieties on the major events of HIV-1 transmission. Compared to viruses with less oligomannose and more complex Env glycans, viruses with more oligomannose and less complex glycans more efficiently (i) transcytosed across an epithelial cell monolayer, (ii) attached to monocyte-derived macrophages
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/EE2.3.20.0164" target="_blank" >EE2.3.20.0164: International research network</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)