High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150787" target="_blank" >RIV/61989592:15110/14:33150787 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0090458" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0090458</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0090458" target="_blank" >10.1371/journal.pone.0090458</a>
Alternative languages
Result language
angličtina
Original language name
High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma
Original language description
Drug repurposing or repositioning is an important part of drug discovery that has been growing in the lask few years for the development of therapeutic options in oncology. We applied this paradigm in a screening of a library of about 3,800 compounds (including FDA-.approved drugs and pharmacologically active compounds) employing a model of metastatic pheochromocytoma, the most common tumor of the adrenal medulla in children and adults. The collection of approved drugs was screened in quantitative mode,testing the compounds in compound-titration series (dose-response curves). Analysis of the dose-response screening data facilitated the selection of 50 molecules with potential bioactivity in pheochromocytoma cells. These drugs were classified based onmolecular/cellular targets and signaling pathways affected, and selected drugs were further validated in a proliferation assay and by flow cytometric cell death analysis. Using metaanalysis information from molecular targets of the top dr
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"e90458-1"-"e90458-11"
UT code for WoS article
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EID of the result in the Scopus database
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