Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150843" target="_blank" >RIV/61989592:15110/14:33150843 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/14:10281589
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1756464614002254" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1756464614002254</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jff.2014.06.026" target="_blank" >10.1016/j.jff.2014.06.026</a>
Alternative languages
Result language
angličtina
Original language name
Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
Original language description
Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements.The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment.The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Functional Foods
ISSN
1756-4646
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
september
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
327-335
UT code for WoS article
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EID of the result in the Scopus database
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