Chelating polymeric beads as potential therapeutics for Wilson's disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150909" target="_blank" >RIV/61989592:15110/14:33150909 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/14:00431233 RIV/00216208:11110/14:10284301
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejps.2014.05.002" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2014.05.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2014.05.002" target="_blank" >10.1016/j.ejps.2014.05.002</a>

Result language
angličtina
Original language name
Chelating polymeric beads as potential therapeutics for Wilson's disease
Original language description
Wilson's disease is a genetic disorder caused by a malfunction of ATPase 7B that leads to high accumulation of copper in the organism and consequent toxic effects. We propose a gentle therapy to eliminate the excessive copper content with oral administration of insoluble non-resorbable polymer sorbents containing selective chelating groups for copper(II). Polymeric beads with the chelating agents triethylenetetramine, N,N-di(2-pyridylmethyl)amine, and 8-hydroxyquinoline (8HQB) were investigated. In a preliminary copper uptake experiment, we found that 8HQB significantly reduced copper uptake (using copper-64 as a radiotracer) after oral administration in Wistar rats. Furthermore, we measured organ radioactivity in rats to demonstrate that 8HQB radiolabelled with iodine-125 is not absorbed from the gastrointestinal tract after oral administration. Non-resorbability and the blockade of copper uptake were also confirmed with small animal imaging (PET/CT) in mice. In a long-term experiment
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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