Detection of Clopidogrel Resistance Using ADP Induced Aggregometry with Specific Inhibitor PGE1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33151350" target="_blank" >RIV/61989592:15110/14:33151350 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/14:#0000777
Result on the web
<a href="http://dx.doi.org/10.7754/Clin.Lab.2013.131004" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2013.131004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7754/Clin.Lab.2013.131004" target="_blank" >10.7754/Clin.Lab.2013.131004</a>
Alternative languages
Result language
angličtina
Original language name
Detection of Clopidogrel Resistance Using ADP Induced Aggregometry with Specific Inhibitor PGE1
Original language description
Backround: Antiaggregation therapy is still the most frequently used approach to prevent thrombotic events in cardiovascular diseases. It has a good clinical effect but increasing evidence shows high residual platelet aggregation activity in a number ofpatients. Laboratory methods only allow us to detect clopidogrel "non-responders" or "low responders". Recent methods are based on monitoring residual platelet aggregation activity (aggregation methods) or detecting the number of free epitopes for binding a specific monoclonal antibody such as vasodilator-stimulated phosphoprotein phosphorylation (VASP). Methods: The aims of our study were comparison light transmission aggregometry (LTA) and multiple electrode platelet aggregometry (MEA) with inductionby ADP in concentrations of 20 mýmol/L with or without prostaglandin E1 (PGE1) for monitoring clopidogrel resistance. Results: In the group of 84 patients with cardiovascular disease (CAD) studied, an impaired individual response to clopi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14394" target="_blank" >NT14394: Tissue factor activation in pregnancy complications</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Laboratory
ISSN
1433-6510
e-ISSN
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Volume of the periodical
60
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
1475-1480
UT code for WoS article
000342857900007
EID of the result in the Scopus database
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