The advantages and limitations of impedance aggregometry in detection of heparin-induced thrombocytopenia.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33151355" target="_blank" >RIV/61989592:15110/14:33151355 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/14:#0000778

Result on the web

<a href="http://dx.doi.org/10.7754/Clin.Lab.2013.130740" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2013.130740</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7754/Clin.Lab.2013.130740" target="_blank" >10.7754/Clin.Lab.2013.130740</a>

Result language

angličtina

Original language name

The advantages and limitations of impedance aggregometry in detection of heparin-induced thrombocytopenia.

Original language description

BACKGROUND: Heparin-induced thrombocytopenia (HIT) represents a serious complication of heparin treatment. IgG antibodies binding platelet factor 4 (PF4) and heparin trigger the clinical manifestations of HIT. However, only a portion of the antibodies have the ability to activate platelets, and these can be identified by a platelet aggregation test (functional testing). Current methods HIPA and SRA are time-consuming and difficult if HIT is clinically suspected; therefore, numerous new methods have recently been developed. METHODS: To determine HIT, impedance aggregometry using the Multiplate analyzer (MEA) as heparin-induced aggregation techniques and the Technozym HIT Ig ELISA test were used. The MEA method uses sensitization of donor platelets withpatient plasma in the presence of heparin at a concentration of 0.5 IU/mL. The results were compared with the ELISA test. RESULTS: We examined 190 patients at clinically intermediate and higher risk of HIT according to the 4T score. All s

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT14394" target="_blank" >NT14394: Tissue factor activation in pregnancy complications</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Laboratory

ISSN

1433-6510

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

1319-1324

UT code for WoS article

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EID of the result in the Scopus database

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