Polymorphism of the Fc? Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154990" target="_blank" >RIV/61989592:15110/15:33154990 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.7754/Clin.Lab.2015.141207" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2015.141207</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7754/Clin.Lab.2015.141207" target="_blank" >10.7754/Clin.Lab.2015.141207</a>

Result language

angličtina

Original language name

Polymorphism of the Fc? Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia

Original language description

Background: Heparin-induced thrombocytopenia (HIT) represents a serious complication of heparin treatment. IgG antibodies binding platelet factor 4 (PF4) and heparin trigger the clinical manifestations of HIT. However, only a portion of the antibodies have the ability to activate platelets, and these can be identified by a platelet aggregation test (functional testing). However, this expression has been detected to have a molecular cause, which is a mutation of Fc?RIIa. The Fc?RIIa receptor is responsible for the activation of platelets by antibodies in HIT. Methods: To determine HIT, impedance aggregometry using the Multiplate analyzer (MEA) as heparin-induced aggregation technique and the Technozym HIT IgG ELISA test were used. The MEA method uses sensitization of donor platelets with patient plasma in the presence of heparin at a concentration of 0.5 IU/mL. The results were compared with the ELISA test. Mutation of Fc?RIIa was assessed using the asymmetric real-time PCR method that

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT14394" target="_blank" >NT14394: Tissue factor activation in pregnancy complications</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Laboratory

ISSN

1433-6510

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

1027-1032

UT code for WoS article

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EID of the result in the Scopus database

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