Efficacy and safety of ivabradine in patients with chronic systolic heart failure according to blood pressure level in SHIFT.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33152244" target="_blank" >RIV/61989592:15110/14:33152244 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejhf.114" target="_blank" >http://dx.doi.org/10.1002/ejhf.114</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejhf.114" target="_blank" >10.1002/ejhf.114</a>

Result language
angličtina
Original language name
Efficacy and safety of ivabradine in patients with chronic systolic heart failure according to blood pressure level in SHIFT.
Original language description
AIMS: Low systolic blood pressure (SBP) is associated with poor outcomes in heart failure and complicates management. In a post hoc analysis, we investigated the efficacy and safety of ivabradine in the SHIFT population divided by tertiles of baseline SBP. METHODS AND RESULTS: The analysis comprised 2110 patients with SBP {115 mmHg, 1968 with 115? SBP {130 mmHg, and 2427 with SBP ?130 mmHg. Patients with low SBP were younger, had lower ejection fraction, and were less likely to be at target beta-blockerdose than patients in the other SBP groups. Ivabradine was associated with a similar relative risk reduction of the composite outcome in the three SBP groups [SBP {115 mmHg, hazard ratio (HR) = 0.84, 95% confidence interval (CI) 0.72-0.98; 115? SBP {130mmHg, HR = 0.86, 95% CI 0.72 to 1.03; SBP ?130 mmHg, HR = 0.77, 95% CI 0.66 to 0.92; P interaction = 0.68]. Similar results were found for cardiovascular mortality (P interaction = 0.91), hospitalization because of heart failure (P inter
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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