Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33153071" target="_blank" >RIV/61989592:15110/14:33153071 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014010825" target="_blank" >http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014010825</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014010825" target="_blank" >10.1615/JLongTermEffMedImplants.2014010825</a>
Alternative languages
Result language
angličtina
Original language name
Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview
Original language description
The innate immune system consists of functionally specialized "modules" that are activated in response to a particular set of stimuli via sensors located on the surface or inside the tissue cells. These cells screen tissues for a wide range of exogenousand endogenous danger/damage-induced signals with the aim to reject or tolerate them and maintain tissue integrity. In this line of thinking, inflammation evolved as an adaptive tool for restoring tissue homeostasis. A number of diseases are mediated bya maladaptation of the innate immune response, perpetuating chronic inflammation and tissue damage. Here, we review recent evidence on the cross talk between innate immune sensors and development of rheumatoid arthritis, osteoarthritis, and aseptic loosening of total joint replacements. In relation to the latter topic, there is a growing body of evidence that aseptic loosening and periprosthetic osteolysis results from long-term maladaptation of periprosthetic tissues to the presence of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Long-Term Effects of Medical Implants
ISSN
1050-6934
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
297-317
UT code for WoS article
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EID of the result in the Scopus database
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