Periprosthetic inflammation: From the cellular level to clinical implications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00142267" target="_blank" >RIV/00216224:14110/25:00142267 - isvavai.cz</a>

Result on the web

<a href="https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf154/8257522" target="_blank" >https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf154/8257522</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jbmrpl/ziaf154" target="_blank" >10.1093/jbmrpl/ziaf154</a>

Result language

angličtina

Original language name

Periprosthetic inflammation: From the cellular level to clinical implications

Original language description

Periprosthetic inflammation is a crucial factor contributing to aseptic loosening, the leading cause of implant failures. Metallic debris, including nanoparticles, sub-micron particles, and ions, plays a central role in triggering inflammatory responses around orthopaedic implants. Exposure to the debris activates macrophages via Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which in turn leads to the production of pro-inflammatory cytokines. This signalling cascade subsequently drives osteoclast activation, resulting in periprosthetic bone loss and, ultimately, implant loosening. Recent research has focused on strategies to prevent aseptic loosening by targeting the inflammation induced by metallic particles/ions. Pharmacological interventions aimed at modulating macrophage activation and inhibiting specific inflammatory pathways have shown promise in reducing osteoclast activity and excessive bone resorption. This review provides a comprehensive overview of the processes involved in the pathogenesis of periprosthetic inflammation, beginning with the release of metallic debris and its recognition by immune cells, followed by the inflammatory reactions that lead to osteoclastogenesis and bone loss. A detailed understanding of these molecular mechanisms is essential for the development of targeted approaches to prevent aseptic loosening, improve long-term patient outcomes, and alleviate the economic burden on healthcare systems.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30211 - Orthopaedics

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JBMR PLUS

ISSN

2473-4039

e-ISSN

2473-4039

Volume of the periodical

9

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1-14

UT code for WoS article

001593825900001

EID of the result in the Scopus database

2-s2.0-105019528592