Macrophages-Key cells in the response to wear debris from joint replacements.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33148509" target="_blank" >RIV/61989592:15110/13:33148509 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jbm.a.34599" target="_blank" >http://dx.doi.org/10.1002/jbm.a.34599</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.a.34599" target="_blank" >10.1002/jbm.a.34599</a>

Result language
angličtina
Original language name
Macrophages-Key cells in the response to wear debris from joint replacements.
Original language description
The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone destruction, and eventually, implant loosening, and revision surgery. The latter may be indicated in up to 15% patients in the decade following the arthroplasty using conventional polyethylene. Macrophages play multiple roles in both inflammation and in maintaining tissue homeostasis. Assentinels of the innate immune system, they are central to the initiation of this inflammatory cascade, characterized by the release of proinflammatory and pro-osteoclastic factors. Similar to the response to pathogens, wear particles elicit a macrophage response, based on the unique properties of the cells belonging to this lineage, including sensing, chemotaxis, phagocytosis, and adaptive stimulation. The biological processes involved are complex, redundant, both local and systemic, a
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
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Project
<a href="/en/project/NT11049" target="_blank" >NT11049: Gene expression profiling of the periprosthetic tissues: first step toward time-dependent analysis of periprosthetic osteolysis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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