Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33143644" target="_blank" >RIV/61989592:15110/13:33143644 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/13:#0000488

Result on the web

<a href="http://dx.doi.org/10.1177/1753425912451779" target="_blank" >http://dx.doi.org/10.1177/1753425912451779</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1753425912451779" target="_blank" >10.1177/1753425912451779</a>

Result language

angličtina

Original language name

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

Original language description

Numerous studies provide detailed insight into the triggering and amplification mechanisms of the inflammatory response associated with prosthetic wear particles, promoting final dominance of bone resorption over bone formation in multiple bone multicellular units around an implant. In fact, inflammation is a highly regulated process tightly linked to simultaneous stimulation of tissue protective and regenerative mechanisms in order to prevent collateral damage of periprosthetic tissues. A variety of cytokines, chemokines, hormones and specific cell populations, including macrophages, dendritic and stem cells, attempt to balance tissue architecture and minimize inflammation. Based on this fact, we postulate that the local tissue homeostatic mechanismsmore effectively regulate the pro-inflammatory/pro-osteolytic cells/pathways in patients with none/mild periprosthetic osteolysis (PPOL) than in patients with severe PPOL. In this line of thinking, 'particle disease theory' can be underst

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FI - Traumatology and orthopaedics

OECD FORD branch

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Project

<a href="/en/project/NT11049" target="_blank" >NT11049: Gene expression profiling of the periprosthetic tissues: first step toward time-dependent analysis of periprosthetic osteolysis</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Innate Immunity

ISSN

1662-811X

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

213-224

UT code for WoS article

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EID of the result in the Scopus database

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