Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154230" target="_blank" >RIV/61989592:15110/15:33154230 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1165/rcmb.2014-0294TR" target="_blank" >http://dx.doi.org/10.1165/rcmb.2014-0294TR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1165/rcmb.2014-0294TR" target="_blank" >10.1165/rcmb.2014-0294TR</a>
Alternative languages
Result language
angličtina
Original language name
Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies
Original language description
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the most intensively studied families of growth factors in the last four decades. PDGF signaling plays an essential role in cell proliferation, differentiation, migration, and survival. In vivo studies have documented an important role of PDGF signaling in the normal development of several organs, such as the kidney, eye, or lung. PDGF signaling is essential for the formation of intact mesenchymal cells during embryogenesis. Recently, this knowledge has been extended to a role of PDGF signaling in diseases in general, such as cancer and atherosclerosis, and more importantly in lung diseases, including pulmonary arterial hypertension, lung cancer, and lung fibrosis. Inthis review, we provide an up-to-date overview of PDGF signaling, including tissue- and cell-type-specific expression patterns and effects. We highlight current therapeutic approaches modifying PDGF signaling in lung diseases and summari
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Respiratory, Cell and Molecular Biology (print)
ISSN
1044-1549
e-ISSN
—
Volume of the periodical
52
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
22
Pages from-to
263-284
UT code for WoS article
000352208100001
EID of the result in the Scopus database
—