In Vitro AuNPs' Cytotoxicity and Their Effect on Wound Healing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154260" target="_blank" >RIV/61989592:15110/15:33154260 - isvavai.cz</a>

Result on the web

<a href="http://cdn.intechopen.com/pdfs-wm/48665.pdf" target="_blank" >http://cdn.intechopen.com/pdfs-wm/48665.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/61132" target="_blank" >10.5772/61132</a>

Result language

angličtina

Original language name

In Vitro AuNPs' Cytotoxicity and Their Effect on Wound Healing

Original language description

Recently, due to their unique properties, gold nanoparticles (AuNPs) have been used in many biological applications. However, little is known about their toxicity when they come into contact with a biological system. Based on the proposal that AuNPs canhave a positive effect on wound healing, the present study investigated the influence of negatively-charged-surface AuNPs (average diameter 25-50 nm) on the viability of normal human dermal fibroblasts (NHDF) and normal human epidermal keratinocytes (NHEK). Moreover, we evaluated the effect of AuNPs on the secretion of proteins involved in wound healing, such as interleukin-8 and -12 (IL-8, IL-12), tumour necrosis factor-alpha (TNF-?), vascular endothelial growth factor (VEGF), basic fibroblast grow factor (bFGF), and granulocyte-macrophage colony-stimulating factor (GM-CSF). The results showed that AuNPs were not toxic to NHDF and NHEK. They showed a decrease in AuNPs' production of pro-inflammatory cytokines IL-6, IL-12 and TNF-?, as

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanobiomedicine

ISSN

1849-5435

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

7

Country of publishing house

HR - CROATIA

Number of pages

7

Pages from-to

1-7

UT code for WoS article

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EID of the result in the Scopus database

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