Polyamine derivatives of betulinic acid and beta-sitosterol: A comparative investigation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154369" target="_blank" >RIV/61989592:15110/15:33154369 - isvavai.cz</a>

Alternative codes found

RIV/61389030:_____/15:00447202 RIV/61388963:_____/15:00447202 RIV/60461373:22330/15:43899475

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polyamine derivatives of betulinic acid and beta-sitosterol: A comparative investigation

Original language description

beta-Sitosterol and betulinic acid were used in designing their conjugates with selected polyamines bearing either an amide bond, or an ester and an amide bond simultaneously in the target molecule. The synthesized compounds were subjected to basic cytotoxic and antimicrobial tests. The synthetic protocol is described separately for each of the three series of the target amides, because each series of compounds required a different synthetic approach. The cytotoxicity was tested on cells derived from human T-lymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with the tests on normal human fibroblasts. Most of the target compounds (5a-5c, 11a-11c and 16a-16c) showed medium to high cytotoxicity (0.7-7.8 mu M), however, in some cases the compounds showed high cytotoxicity even toward normal human fibroblasts (11a-11c). Two compounds of this series (11c and 16c) also displayed antimicrobial activity with high and selective microbe specificity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Elsevier Science

ISSN

0039-128X

e-ISSN

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Volume of the periodical

100

Issue of the periodical within the volume

AUG

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

27-35

UT code for WoS article

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EID of the result in the Scopus database

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