Amides derived from heteroaromatic amines and selected steryl hemiesters

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147873" target="_blank" >RIV/61989592:15310/13:33147873 - isvavai.cz</a>

Alternative codes found

RIV/61389030:_____/13:00398419 RIV/61388963:_____/13:00398419 RIV/61989592:15110/13:33147873 RIV/60461373:22330/13:43895382

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0039128X13002171" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X13002171</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.steroids.2013.10.003" target="_blank" >10.1016/j.steroids.2013.10.003</a>

Result language

angličtina

Original language name

Amides derived from heteroaromatic amines and selected steryl hemiesters

Original language description

The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 m

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Steroids

ISSN

0039-128X

e-ISSN

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Volume of the periodical

78

Issue of the periodical within the volume

14

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1347-1352

UT code for WoS article

000328303300006

EID of the result in the Scopus database

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