Folate receptor: a potential target in ovarian cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33155448" target="_blank" >RIV/61989592:15110/15:33155448 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1515/pterid-2014-0013" target="_blank" >http://dx.doi.org/10.1515/pterid-2014-0013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/pterid-2014-0013" target="_blank" >10.1515/pterid-2014-0013</a>

Result language

angličtina

Original language name

Folate receptor: a potential target in ovarian cancer

Original language description

Ovarian cancer is the most frequent cause of gynecological cancer-related death. Unfortunately, many patients are diagnosed at an advanced stage and have a poor prognosis. The standard treatment for advanced disease involves maximal cytoreductive surgeryand chemotherapy based on platinum compounds and taxanes. Patients presenting at an advanced stage have a higher risk of recurrence. The development of drug resistance currently represents a major obstacle in the systematic treatment and, therefore, thediscovery of new anticancer agents and approaches should improve the poor prognosis of these patients. Folate receptor a is overexpressed in epithelial ovarian cancer (EOC), but has limited expression in nonmalignant human tissues. The degree of folatereceptor expression corresponds with the stage and grade of the disease. Because of this, folate receptor a seems to be a potential therapeutic target for the treatment of ovarian cancer. Currently, several approaches have been studied to

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pteridines

ISSN

0933-4807

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

1-12

UT code for WoS article

—

EID of the result in the Scopus database

—