SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33155690" target="_blank" >RIV/61989592:15110/15:33155690 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/onc.2015.24" target="_blank" >http://dx.doi.org/10.1038/onc.2015.24</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/onc.2015.24" target="_blank" >10.1038/onc.2015.24</a>

Result language

angličtina

Original language name

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Original language description

Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste, Trithorax-domain containing 2) trimethylates histone-3 lysine-36 (H3K36me3) at sites of active transcription and is mutated in diverse tumour types, including clear cell renal carcinomas (ccRCCs). Distinct SETD2 mutations have been identified in spatially separated regions in ccRCC, indicative of intratumour heterogeneity. In this study, we have addressed the consequences of SETD2 loss-of-function through an integrated bioinformatics and functional genomics approach. We find that bi-allelic SETD2 aberrations are not associated with microsatellite instability in ccRCC. SETD2 depletion in ccRCC cells revealed aberrant and reduced nucleosome compaction and chromatin association of the key replication proteins minichromosome maintenance complex component (MCM7) and DNA polymerase delta hinder

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

46

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

5699-5708

UT code for WoS article

000364594600002

EID of the result in the Scopus database

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