Solid-Supported Hydrazone of 4-(4'-Formyl-3'-methoxyphenoxy)butyric Acid As a New Traceless Linker for Solid-Phase Synthesis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33156120" target="_blank" >RIV/61989592:15110/15:33156120 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/15:33156120
Result on the web
<a href="http://pubs.acs.org/doi/abs/10.1021/ol5034223" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/ol5034223</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/ol5034223" target="_blank" >10.1021/ol5034223</a>

Result language
angličtina
Original language name
Solid-Supported Hydrazone of 4-(4'-Formyl-3'-methoxyphenoxy)butyric Acid As a New Traceless Linker for Solid-Phase Synthesis
Original language description
The use of a hydrazine derived from a backbone amide linker as a new hydrazone-based traceless linker for solid-phase organic synthesis is described. The stability of the linker was tested under various conditions, including treatment with acids, bases, and borohydrides. Final compounds can be released by selective cleavage using trimethylsilanolate. To demonstrate the versatility of the linker, the synthesis of a model compound under various reaction conditions was performed with good results.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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