Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00569335" target="_blank" >RIV/61388963:_____/23:00569335 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00569335 RIV/60461373:22310/23:43927868 RIV/68407700:21460/23:00365020 RIV/00216208:11310/23:10458206
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB02235D" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB02235D</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2ob02235d" target="_blank" >10.1039/d2ob02235d</a>

Result language
angličtina
Original language name
Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters
Original language description
Galectins are lectins that bind beta-galactosides. They are involved in important extra- and intracellular biological processes such as apoptosis, and regulation of the immune system or the cell cycle. High-affinity ligands of galectins may introduce new therapeutic approaches or become new tools for biomedical research. One way of increasing the low affinity of beta-galactoside ligands to galectins is their multivalent presentation, e.g., using calixarenes. We report on the synthesis of glycocalix[4]arenes in cone, partial cone, 1,2-alternate, and 1,3-alternate conformations carrying a lactosyl ligand on three different linkers. The affinity of the prepared compounds to a library of human galectins was determined using competitive ELISA assay and biolayer interferometry. Structure-affinity relationships regarding the influence of the linker and the core structure were formulated. Substantial differences were found between various linker lengths and the position of the triazole unit. The formation of supramolecular clusters was detected by atomic force microscopy. The present work gives a systematic insight into prospective galectin ligands based on the calix[4]arene core.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)