Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33156620" target="_blank" >RIV/61989592:15110/15:33156620 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking

Original language description

Chemokine receptors and their ligands, key mediators of immune cell trafficking, have been critically involved in chronic lung diseases and their potential as therapeutic targets is currently being widely investigated. The discovery that chemokine receptors/chemokines, typically expressed by immune cells, are also expressed in structural lung cells reinforces significantly the evidence about their potential to mediate processes towards the restoration of normal lung functions. Besides cell migration, chemokine receptors and their ligands have been shown to regulate also other functions in the lung tissue, such as cell proliferation, mucin secretion, and collagen synthesis. Thus chemokine receptors/chemokines contribute not only to immune responses in the lung, but play a critical role also in the regulation of lung tissue repair and regeneration. This review aims to summarize current state-of-the-art on chemokine receptors and their ligands in chronic lung diseases and their therapeutic potential. Next, it aims to delineate the contribution of chemokine receptors to the processes leading to repair/regeneration of the lung tissue.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

<a href="/en/project/NT11117" target="_blank" >NT11117: Study of mediators of fibrotic processes in patients with diffuse lung diseases and their clinical application</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American journal of physiology. Lung cellular and molecular physiology

ISSN

1522-1504

e-ISSN

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Volume of the periodical

308

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

"L-603"-"L-618"

UT code for WoS article

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EID of the result in the Scopus database

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