Posterior vs. anterior circulation infarction: demography, outcomes, and frequency of hemorrhage after thrombolysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A73576302" target="_blank" >RIV/61989592:15110/15:73576302 - isvavai.cz</a>

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/26310390" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/26310390</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ijs.12626" target="_blank" >10.1111/ijs.12626</a>

Result language

angličtina

Original language name

Posterior vs. anterior circulation infarction: demography, outcomes, and frequency of hemorrhage after thrombolysis

Original language description

BACKGROUND: Intravenous thrombolysis is considered to be the standard specific reperfusion therapy in acute ischemic stroke in both anterior and posterior cerebral circulation. AIMS: Our aim was to evaluate the 90-day outcome and rate of intracranial hemorrhage after recombinant tissue plasminogen activator administration in posterior circulation stroke and to compare the intracranial hemorrhage risk for posterior circulation stroke and anterior circulation stroke. METHODS: The set consisted of 877 consecutive acute ischemic stroke patients (777 anterior circulation stroke; 100 posterior circulation stroke) who underwent intravenous thrombolysis with recombinant tissue plasminogen activator in a standard dose of 0.9 mg/kg. The role of following factors was assessed: presenting characteristics, intracranial hemorrhage classification according to ECASS I, mortality, and 90-day clinical outcome assessed using the modified Rankin scale. RESULTS: Good clinical outcomes (modified Rankin scale 0-2) were noted in 59% of posterior circulation stroke patients, with a mortality rate of 19%. Intracerebral hemorrhage was significantly less frequent in posterior circulation stroke than in anterior circulation stroke patients (5.1 vs. 17.2%; P = 0.002). The risk of large hemorrhage (parenchymal hematoma 1 and 2) was 5.2 times higher in anterior circulation stroke patients (P = 0.007). The following additional statistically significant differences were found between posterior circulation stroke and anterior circulation stroke patients: median age, male gender, presence of atrial fibrillation, hyperlipidemia, median time to treatment, and median blood glucose level on admission.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Stroke

ISSN

1747-4930

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1224-1228

UT code for WoS article

000367673700014

EID of the result in the Scopus database

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