Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33156192" target="_blank" >RIV/61989592:15110/16:33156192 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00005-015-0375-5" target="_blank" >http://link.springer.com/article/10.1007%2Fs00005-015-0375-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00005-015-0375-5" target="_blank" >10.1007/s00005-015-0375-5</a>

Result language
angličtina
Original language name
Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease
Original language description
Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation associated with chronic inflammation. Matrix metalloproteinases (MMPs) are proteolytic enzymes that contribute to the inflammatory response in COPD and degrade extracellular matrix components. Their enzymatic activity is inhibited by a fourmember family of tissue inhibitors of metalloproteinases (TIMPs). In COPD, the MMP/TIMP network, mainly MMP-9, has been repeatedly observed to be dysregulated at both the local (lung) and systemic levels. Here, we review the findings reported in numerous cross-sectional studies with our primary focus on longitudinal observations in human COPD studies. The data from longitudinal prospective studies on the MMP/TIMP network may lead to the introduction of novel prognostic biomarkers into clinical management of COPD. We address the relationship between the systemic and local lung MMP/TIMP network in COPD patients and briefly describe the involvement of microRNAs. Finally, the role of the MMP/TIMP network in COPD treatment is discussed.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/EE2.3.30.0004" target="_blank" >EE2.3.30.0004: POST-UP</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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