18F-FDG PET/CT in the Initial Assessment and for Follow-up in Patients With Tuberculosis.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33156572" target="_blank" >RIV/61989592:15110/16:33156572 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/RLU.0000000000001102" target="_blank" >http://dx.doi.org/10.1097/RLU.0000000000001102</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/RLU.0000000000001102" target="_blank" >10.1097/RLU.0000000000001102</a>
Alternative languages
Result language
angličtina
Original language name
18F-FDG PET/CT in the Initial Assessment and for Follow-up in Patients With Tuberculosis.
Original language description
PURPOSE: The aim of this retrospective study was to assess the value of F-FDG PET/CT in the initial evaluation and follow-up of patients with tuberculosis (TB). PATIENTS AND METHODS: Thirty-five patients (18 men) with pulmonary or extrapulmonary TB were included. Diagnosis of TB was based either on histology or microbiological assessment in 32 patients and was based on typical morphological features of TB in CT and improvement on antimycobacterial medication in 3 patients. Eighty-eight F-FDG PET/CT scans were performed at initial assessment and during treatment, on a Siemens Biograph PET/CT. Diagnostic contrast-enhanced CT scans were performed on the 40-slice multidetector CT of the PET/CT scanner. Mean (SD) anti-TB treatment duration was 16.1 (8.9) months. RESULTS: The initial F-FDG PET identified 64 affected regions in 34 among 35 patients, whereas CT identified 34 affected organs in 23 patients. Matching image results between PET and CT were observed at first visit in 11 patients (31.4%), with relevant differences in 23 (65.7%). In 1 patient, both modalities remained negative. During follow-up F-FDG PET scans, we recorded 15 cases with remission of disease, 16 with residual disease (2 patients with multidrug-resistant infection), and 4 cases with progressive disease or delayed onset of adequate immunological response. In only 3 patients, both modalities, PET and CT, showed completely equivalent results. CONCLUSIONS: Both components of F-FDG PET/CT provide complementary information at initial evaluation and during follow-up; however, F-FDG showed more abnormal findings than CT. F-FDG PET/CT might be useful for the establishment of individualized treatment regimes, but this requires further prospective studies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Nuclear Medicine
ISSN
0363-9762
e-ISSN
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Volume of the periodical
APR
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"e-187"-"e-194"
UT code for WoS article
000372214600003
EID of the result in the Scopus database
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